John Paul Pezacki

University of Ottawa
2017

John Paul Pezacki obtained his PhD in organic chemistry from McMaster University with the late John Warkentin, conducted postdoctoral studies at the University of Toronto on protein bioconjugation and cross-linking as well as nitric oxide signaling with Ronald Kluger, and then at the Scripps Research Institute with Peter G. Schultz working on a genomic approaches to the study of viral infections. He is a full professor at the University of Ottawa where the overarching theme of his research program is the development and application of chemical tools for the study of host-pathogen interactions. Recent advances include the development of bioorthogonal and activity-based probes with unique chemical reactivity, the identification of cellular factors influencing the virulence of RNA viruses, such as hepatitis C virus, as well as the development of tools to investigate the mechanisms of action of non-coding RNAs during infection and the host response. The discoveries that stem from the development and application of these new chemical/biochemical methodologies are the result of his continuing efforts to elucidate biological mechanisms of infection and identify targets for therapeutic intervention.